Project
Gut-Brain Synergy: Development of an advanced microfluidic model of the microbiota-gut-brain axis to study mechanisms of neurodegenerative diseases
Project description
This project aims to develop a cutting-edge Microbiota-Gut-Brain Axis on Chip (MGBA-on-Chip) platform, a type of organ-on-chip system. Organ-on-chip technology involves creating miniature, functional replicas of human organs within microfluidic devices, allowing for the study of disease mechanisms and testing of new therapies in a human-relevant environment. Our MGBA-on-Chip model will integrate human intestinal epithelial cells, neuronal cells derived from human pluripotent stem cells (hiPSCs), and microbiota. This model will simulate the complex interactions within the GBA, providing valuable insights into how the gut microbiota influences brain function and contributing to our understanding of neurodegenerative disorders.
Funding
Project funded by the National Science Center
Leader
Warsaw University of Technology
Project no
UMO-2024/55/D/ST4/02457
Project value
1 790 594 PLN