Project
Is organ-on-a-chip able to reduce animal sacrifice in studies on radiosensitizers?
Description
The primary objective of the current application is to ascertain whether Organ-on-a-Chip (OoC) technology can effectively replace or at least reduce the number of animals used in in vivo preclinical studies. To demonstrate the feasibility of this substitution, the focus will be on investigating radiosensitizers for radiotherapy. Radiotherapy presents particular challenges for preclinical studies due to the complexities involved. Unlike other modalities, such as chemotherapy, radiotherapy requires evaluating both the toxicity and efficacy of a compound, including its impact on tumor response to ionizing radiation. Additionally, the specialized equipment needed for radiotherapy experiments, such as radiation sources, is not commonly available in animal facilities, further complicating preclinical studies in this field.
Funding
Project funded by the National Science Center
Leader
University of Gdansk
Partner
Warsaw University of Technology
Project No
UMO-2024/53/B/ST4/00570
Project value
4 717 620,00 PLN